Methal wrote:After nearly 10 years of thousands to millions of computers folding you'd think we'd have folded everything to fold including the laundry.
codysluder wrote:From a non-scientific perspective, I'd think that there's one more question, but I guess you'd include it in the second one.
If the answer to question 1 is this sequence produces this final structure, then how can there ever be anything called "mis-folding"? It seems obvious to me that if 98% of the time the normal shape is produced and 2% of the time people develop a life-threatening disease, somebody needs to know WHY, before they can attempt to figure out what to do about it.
Methal wrote:I do have one more important question.
Right now my i7 laptop is working on an a1 (whatever that is....?!) with roughly 20% of my CPU give or take 5-10%
what is it doing? this processor can do trillions, if not thousands of trillions of operations per second. Why does it take so long to do what its doing with whatever this thing is?
I know there are millions upon millions of different ways one protein can fold. If its a simple matter of covalent, or hydrogen bonds, shouldn't folding one protein take a computer like this one half a second to fold it every possible way?
Methal wrote:and if diseases are created by a protein miss-folding, why don't they take the miss-folded protein and investigate ways to refold it? introductions of amino acids that break down the broken proteins or something. (or little nano bots with lazers....i'm sure that would be just as easy =/)
ihaque wrote:Hi Methal,Methal wrote:After nearly 10 years of thousands to millions of computers folding you'd think we'd have folded everything to fold including the laundry.
Your position is perfectly reasonable. Fortunately for those of us still working in the field, it's not true . There are, in fact, two distinct questions related to folding, both of which are still considered open problems.
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