Folding Forum

I read somewhere that it was on the order of 10^39 possible "folds" but only 1 out of 10^39 is a stable state

For any given single protein I understand there is only one correct fold, but how many mis-folds can there be? I'm assuming it is a very large number?

Okay, thanks.

Here's a tip. Eat raw garlic (uncooked). It makes the pitch of the sound go high, that it almost goes away. Try 2 or 3 cloves in a sandwich.

Improved algorithms is what is needed.

Jesse_V and Bruce,

Thanks very much --- this is clearer to me now. I'll just let my machine fold ... and if I come up with anymore questions, I'll just ask or do a bit more reading in the FAQ or Papers. Protein folding is very interesting.

Does the rRNA link the amino acids together in linear sequential order from 1st amino acid to nth amino acid, or... does the rRNA create segments of the protein in random order (directed by mRNA) --- then assemble the final protein by linking all segments together --- similar to the way packets are...

Does the rRNA link the amino acids together in linear sequential order from 1st amino acid to nth amino acid, or... does the rRNA create segments of the protein in random order (directed by mRNA) --- then assemble the final protein by linking all segments together --- similar to the way packets are ...

No. Folding is pretty serial. You need to know where the atoms in the protein move next before you can calculate where they will move after that. Stanford essentially breaks it down for us to the WU level and even that is a very short time frame. What do you exactly mean by, " You need to know...

Can a WU be divided up into smaller WU_subsets such that the smaller WU_subsets are sent off the other CPU's for parallelization? Has anyone investigated this option?

The video implies that FAH will run in the backgorund and that you will not notice any changes, that is a lie. My surfing is much slower, my upload and download times have increased, accessing web sites is much slower, and the (Not Responding) notification is appearing more frequently. So... I'd say...

My posts my seem deficient in worldly wisdom, though I'm not a biochemist, I make posts from a brainstorming perspective -- in hopes that the posts will inspire a new line of thought.

Let me restate my case in a different way. Let's look at the amino acid "Leucine". If one of the CARBON atoms is an Isotope with a mass different from Carbon 12, then the side chain will have a mass that is different from Carbon 12. Under nanoscales, say Carbon 13, would be a very large ch...

I going to throw onto the table here... an idea that may cause misfolds. It's just a thought. What if the physical geometry of the hydrophobic amino acid sections ... with respect to the entire protein ... are the key to how the protein folds? Let me explain. Specifically ... side chain hydrophobes ...