Fasting slows spread of cancer

[alanazar]

Go to link for video interview
http://www.futurity.org/health-medicine ... of-cancer/

USC (US) — Cancer in animals appears less resilient, judging by a study that found chemotherapy drugs work better when combined with cycles of short, severe fasting.
Even fasting on its own effectively treated a majority of cancers tested in animals, including cancers from human cells.
The study, published in the journal Science Translational Medicine, found that five out of eight cancer types in mice responded to fasting alone: Just as with chemotherapy, fasting slowed the growth and spread of tumors.

Straight from the Source
Read the original study
DOI: 10.1126/scitranslmed.3003293
And without exception, “the combination of fasting cycles plus chemotherapy was either more or much more effective than chemo alone,” says senior author Valter Longo, professor of gerontology and biological sciences at the University of Southern California.
For example, multiple cycles of fasting combined with chemotherapy cured 20 percent of mice with a highly aggressive type of children’s cancer that had spread throughout the organism and 40 percent of mice with a more limited spread of the same cancer.
No mice survived in either case if treated only with chemotherapy.
Only a clinical trial lasting several years can demonstrate whether humans would benefit from the same treatment, Longo cautions.
Results from the first phase of a clinical trial with breast, urinary tract, and ovarian cancer patients, conducted at the USC Norris Comprehensive Cancer Center and led by oncologists Tanya Dorff and David Quinn, in collaboration with Longo, have been submitted for presentation at the annual meeting of the American Society of Cancer Oncologists.
The first phase tests only the safety of a therapy, in this case whether patients can tolerate short-term fasts of two days before and one day after chemotherapy.
“We don’t know whether in humans it’s effective,” Longo says of fasting as a cancer therapy. “It should be off limits to patients, but a patient should be able to go to their oncologist and say, ‘What about fasting with chemotherapy or without if chemotherapy was not recommended or considered?”
In a case report study with self-reported data published in the journal Aging in 2010, 10 cancer patients who tried fasting cycles perceived fewer side effects from chemotherapy.
Safety issues
Longo stresses that fasting may not be safe for everyone. The clinical trial did not enroll patients who already had lost more than 10 percent of their normal weight or who had other risk factors, such as diabetes. Fasting also can cause a drop in blood pressure and headaches, which could make driving and other activities dangerous for some patients.
In mice, the study found that fasting cycles without chemotherapy could slow the growth of breast cancer, melanoma, glioma, and human neuroblastoma. In several cases, the fasting cycles were as effective as chemotherapy.
Fasting also extended survival in mice bearing a human ovarian cancer. In the case of melanoma, the cancer cells became resistant to fasting alone after a single round, but the single cycle of fasting was as effective as chemotherapy in reducing the spread of cancer to other organs.
For all cancers tested, fasting combined with chemotherapy improved survival, slowed tumor growth, and/or limited the spread of tumors.
As with any potential cancer treatment, fasting has its limits. The growth of large tumor masses was reduced by multiple fasting and chemotherapy cycles, but cancer-free survival could not be achieved. Longo speculates that cells inside a large tumor may be protected in some way or that the variety of mutations in a large mass may make it more adaptable.
But he notes that in most patients, oncologists have at least one chance to attack the cancer before it grows too large.
Longo and collaborators at the National Institute on Aging studied one type of breast cancer in detail to try to understand the effects of fasting.
While normal cells deprived of nutrients enter a dormant state similar to hibernation, the researchers saw that the cancer cells tried to make new proteins and took other steps to keep growing and dividing.
The result, Longo says, was a “cascade of events” that led to the creation of damaging free radical molecules, which broke down the cancer cells’ own DNA and caused their destruction.
“The cell is, in fact, committing cellular suicide. What we’re seeing is that the cancer cell tries to compensate for the lack of all these things missing in the blood after fasting. It may be trying to replace them, but it can’t,” Longo says.
Confuse the cancer
The new study bookends research published in Proceedings of the National Academy of Sciences in 2008.
In that study, Longo’s team showed that fasting protected normal cells against chemotherapy, but did not address the effect on cancer cells. The study also focused only on a single cancer and chemotherapy drug.
The new study on a range of cancers and common chemotherapy drugs extends the 2008 results by showing that fasting not only fails to protect cancer cells, but also makes them more vulnerable.
Longo called the effect “Differential Stress Sensitization” to reflect the change in vulnerability between normal and cancerous cells.
Longo’s interest in fasting and cancer grew from years of studies on the beneficial effects of fasting in yeast and other organisms. He showed 15 years ago that starved yeast cells enter a stress-resistant mode as they wait for better times.
By contrast, he says, the mutations in cancer cells come at a cost, such as a loss in adaptability to diverse environments. For example, Longo found that yeast genetically modified to resemble cancer cells become much more sensitive to several toxins.
“A way to beat cancer cells may not be to try to find drugs that kill them specifically but to confuse them by generating extreme environments, such as fasting that only normal cells can quickly respond to,” Longo says.
Longo’s collaborators were lead authors Changhan Lee, a graduate student in Longo’s laboratory at the USC Davis School of Gerontology, and Lizzia Raffaghello, a researcher at the Giannina Gaslini Institute in Genoa, Italy.
Additional co-authors contributed from USC, the Giannina Gaslini Institute, and the National Institute on Aging.
Funding for the study came from the National Institutes of Health, the Bakewell Foundation, The V Foundation for Cancer Research, the Norris Cancer Center, the Italian Association for Cancer Research, and the Italian Foundation for Cancer Research.

[MtM]

I like reading about these things, but I do have a comment about you posting it here in this form.

If you post them just to start a discussion, post a summary in quote tags with a clear link to the full article. If you post because a particular part seems to be of importance, post the relevant section with link and add to it why you think it's of importance ( what it implies? ).

It's generally not done on any forum to copy paste an entire article, and it can be ill received when not done following certain courtesy standards like I just mentioned.

As to cancer and abstinence of nutrient intake, I don't think many people diagnosed with cancer are capable of doing this without suffering other effects which are not really wanted. I did know that the auto immune system can do wonderfull things, and had heard about it being triggered by 'tricking' the body ( which vasting does, it tricks the body to think there is an imminent danger of failures due to lack of nutrients ). It's nice to hear that a study has proven this ( without having read the source article ), but as I said i don't think it has any practical use unless it also explained why it happens and offers a way to get the same effect without withholding nutrients?

ps. I don't want to sound to negative, it's 2am and I should be on one ear but decided to drop in and read up when your posts caught my eye. As I said, it's nice to see people care enough to post about things they think/feel might be of interest to other people here.

[alanazar]

Hey MtM! No offense taken I actually wanted to ask that same question on how to post these articles but didn't know where (I'm new here). The reason I thought it would be useful are for people on mobiles (like me) that don't want to keep clicking links but I think that's prob a small amount & you're right about posting the most relevant part if it's to start a discussion.

Thanks for the tip & please keep them coming as I'm planning on curating for this section

[Jesse_V]

My sister underwent chemotherapy several years ago. My parents did things to try to keep everyone in a positive outlook, but it was still a eye-opening experience to witness it. We stayed in the Ronald McDonald House (which we help to keep meticulously clean and sterile for obvious reasons) but I've never seen so many people missing hair and eyebrows (this is more noticeable than you might think). There have to be better options than nuking the entire body which chemicals so toxic that it would eat away at one's bladder if it stayed there too long. It's a pretty horrible set of drugs, and though it can be effective, there have to be more chemically surgical options. There are many side effect to them, most notably hair loss and suppressed immune system. Basically the entire body is totally chemically confused. Sometimes it even effects the ability to think straight. Fasting during chemo may work better, but based on what I've seen it's likely going to be impractical. The anti-nausea drugs (which are basically essential) can cause major hunger. Read up on it. Somehow the idea of coordinating sever fasts with chemo with other drugs designed to combat chemo's side effects just seems infeasible to me. I'll bet that the patient would reject the fasting idea. I see that they tried it on people, with interesting results, but I think it really remains to be seen if its really effective and practical on a larger scale.

Have you read up on F@h's efforts toward cancer? I find it pretty impressive. Apparently we were the first distributed computing project to directly produce a publication on cancer research.