Designer Proteins

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Designer Proteins

Postby rbpeake » Thu Dec 28, 2017 1:52 am

Interesting article.

Scientists Are Designing Artisanal Proteins for Your Body
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Re: Designer Proteins

Postby Nert » Thu Dec 28, 2017 4:57 am

Agree ... very interesting. Results from Rosetta at home (not FAH) I believe.
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Re: Designer Proteins

Postby foldy » Thu Dec 28, 2017 11:31 am

So is the puzzle solved already? Or only at the surface?
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Re: Designer Proteins

Postby tcphillips » Thu Dec 28, 2017 1:39 pm

Good article, and informative.... then, to play not-too-serious "straight guy," if this particular problem is "solved," are we (F@H) old news? our work still relevant? Why are we still doing what we're doing...?
(...not that I'm going to quit anytime soon...)


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Re: Designer Proteins

Postby Joe_H » Thu Dec 28, 2017 5:29 pm

From my understanding, Rosetta just gets the researchers a folded state and does not necessarily identify the mechanisms through which a protein reaches that state. It will not also find many of the possible mis-folded states a protein might fall into. These are things that F@H does determine.

So I would say that a portion of the puzzle is solved, but it is going to take more research to see what the details and consequences are connected to a particular protein design. Those are such things as what happens if/when the designed protein mis-folds, and how do possible mutations effect that as well.

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