Folding Forum

Interesting article.

Scientists Are Designing Artisanal Proteins for Your Body https://nyti.ms/2DTx71O

Agree ... very interesting. Results from Rosetta at home (not FAH) I believe.

So is the puzzle solved already? Or only at the surface?

Good article, and informative....

...so then, to play not-too-serious "straight guy," if this particular problem is "solved," are we (F@H) old news?....is our work still relevant? Why are we still doing what we're doing...?
(...not that I'm going to quit anytime soon...)

--T

From my understanding, Rosetta just gets the researchers a folded state and does not necessarily identify the mechanisms through which a protein reaches that state. It will not also find many of the possible mis-folded states a protein might fall into. These are things that F@H does determine.

So I would say that a portion of the puzzle is solved, but it is going to take more research to see what the details and consequences are connected to a particular protein design. Those are such things as what happens if/when the designed protein mis-folds, and how do possible mutations effect that as well.