Projects 9000-9040 psummary doesn't list HIV/AIDS/Bryostatin

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Projects 9000-9040 psummary doesn't list HIV/AIDS/Bryostatin

Postby wuffy68 » Sun Jun 09, 2019 6:52 pm

I was going to promote Folding@Home as part of Pride Month, and all the past work Stanford did on Bryostatin, including HIV/AIDS research through projects 9000-9040... but the project descriptions don't seem to match anymore. BTW, are any current projects besides 9040 helping research immune deficiency? Thanks

Here's an example of one of the projects, 9040: https://apps.foldingathome.org/project?p=9040

These projects used to say :

Project Description:
Bryostatin is a marine natural product that shows promising and unique activity against several diseases (most notably, cancer, HIV/AIDS, and Alzheimer’s). Its main target, protein kinase C (PKC), is a signaling protein central to many cellular functions. In its active form, PKC binds its ligand and is associated with the membrane, but we currently lack structural information about this complex in its membrane microenvironment. The simulations performed on FAH will help to provide a structure to the PKC-ligand-membrane complex. The structure and dynamics of this complex would allow us to understand bryostatin’s binding mode and thus how to modify and tune its structure to improve function or even create new functions as needed for new therapies in the clinic.


Now they say:

Project Description:
The Src family protein tyrosine kinases are enzymes that play key roles in transducing cellular signals regulating cell growth, differentiation, proliferation, migration and survival. These enzymes are responsible for diseases such as cancer in which the cells undergo uncontrolled differentiation. Crystallographic x-ray structures of human c-Src in the inactive and active conformation allow clear structural distinctions to be drawn between the inactive and active states. Those x-ray structures, though rich in information about the two end-points of the activation event...
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Re: Projects 9000-9040 psummary doesn't list HIV/AIDS/Bryost

Postby Nert » Mon Jun 10, 2019 3:57 pm

I don't think that there are any alzheimer's projects as well. I may be wrong, I couldn't find any others on a cursory review. I think Bryostatin was the only one that was related to that research.
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Re: Projects 9000-9040 psummary doesn't list HIV/AIDS/Bryost

Postby gbowman » Mon Jun 10, 2019 7:33 pm

We don't have anything on immune deficiency right now, but are discussing some new collaborations on that topic. More on Alzheimer's coming soon.
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Re: Projects 9000-9040 psummary doesn't list HIV/AIDS/Bryost

Postby wuffy68 » Fri Jun 14, 2019 3:36 am

gbowman wrote:We don't have anything on immune deficiency right now, but are discussing some new collaborations on that topic. More on Alzheimer's coming soon.


Thank you Dr. Bowman ... that's great to hear.

Can you confirm if the project descriptions for 9000-9040 in the psummary are going to be corrected - or are they correct now?
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Re: Projects 9000-9040 psummary doesn't list HIV/AIDS/Bryost

Postby gbowman » Mon Jul 01, 2019 4:22 pm

I believe the work on Bryostatin and Src kinase are both "complete" in the sense that the researchers answered the questions they wanted to address, published the papers, and have now moved on to the next stages of their careers. I'm optimistic the work that has been done will inspire new projects. Certainly there are a number of projects on kinases already and we're looking into doing more related to Bryostatin.
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Re: Projects 9000-9040 psummary doesn't list HIV/AIDS/Bryost

Postby wuffy68 » Wed Jul 31, 2019 5:27 am

gbowman wrote:I believe the work on Bryostatin and Src kinase are both "complete" in the sense that the researchers answered the questions they wanted to address, published the papers, and have now moved on to the next stages of their careers. I'm optimistic the work that has been done will inspire new projects. Certainly there are a number of projects on kinases already and we're looking into doing more related to Bryostatin.


Thank you Dr. Bowman - my concern was the project descriptions for 9000-9040 was lost, or changed inadvertently. The new psummary page project description doesn't mention Bryostatin, or HIV at all! https://apps.foldingathome.org/project?p=9035 Hopefully the original description can be brought back unless it was erroneously categorized under HIV/AIDS rather than cancer (as it is currently)
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