Bryostatin update

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Bryostatin update

Postby lirva1 » Wed Jan 10, 2018 1:14 am

I noticed on my folding window that the Bryostatin project claims:"Bryostatin is a marine natural product that shows promising and unique activity against several diseases (most notably, cancer, HIV/AIDS, and Alzheimer's)"
Is all of this still true?
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Re: Bryostatin update

Postby Joe_H » Thu Jan 11, 2018 3:00 am

Researchers have been looking into Bryostatin since the '70's when it showed activity against a type of cancer in tests screening for possible drugs to treat cancers. All of that statement is still considered true at this point, though some early phase clinical trials in treating cancers have not shown a good enough benefit to risk ratio to continue. Investigations still continue in relation to HIV and Alzheimers.

Work is also being done on synthesizing Byrostatins as it take about a ton of the type of bryozoan producing them to make one gram. Research is also being done on possible simpler analog drugs that would have the same activity, and possibly be more potent or have fewer side effects.

The short of it is that it will take years to adequately investigate the Bryostatins and possible analogs developed based on them. They may find a useful set of drugs through that research, but it is not possible to predict success yet.

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