Wuhan Corona Virus

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Wuhan Corona Virus

Postby wuffy68 » Fri Jan 24, 2020 9:29 am

Looking through past Folding@home projects and papers, I haven't been able to find much on SARS or other Corona viruses ... Although this may be asking a lot - I think to attract new participants in the network, FAH has to become more timely. When I've told people about FAH, their immediate question have been "what are you doing about Ebola?" Zika? West Nile?" Usually their questions relate directly to what's in the news. Would it be possible to create rapid project deployments where the entire consortium could get ahead of the latest issues instead of waiting for six months or a year before building simulations that other labs have already been studying. In this case, even if the study is under a generic corona virus like the common cold - it primes the pump for new participants. #Marketing albeit under some somber pressure.
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Re: Wuhan Corona Virus

Postby JimF » Fri Jan 24, 2020 5:10 pm

Don't they have to get a description of the virus first?

Fast response is great, but they are not in the drug development business. They find interesting weak spots to attack (for example), but I think are not in a position to carry it much beyond that.
However, if paired with their friends at Rosetta, they might be able to come up with something a little beyond that.
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Re: Wuhan Corona Virus

Postby foldy » Fri Jan 24, 2020 5:56 pm

FAH still could run basic research projects somehow related to these viruses which show up every year in asia and africa.
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Re: Wuhan Corona Virus

Postby gbowman » Fri Jan 24, 2020 10:45 pm

These viruses are fascinating. We've recently started working on Ebola and have our first publication on the topic in the works. We also just published our first paper on the SFTS virus.
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Re: Wuhan Corona Virus

Postby JonazzDJ » Sun Jan 26, 2020 10:38 pm

I remember a big outcry a few years ago by folders that some of the biggest FAH projects (at the time) were about the flu. Several people even left the project.
FAH collaborated with the Kasson Lab to better understand membrane fusion in the hope of one day designing antiviral drugs. Now look how important this research can be. Do FAH and Kasson still work together?

IMHO, FAH's viral work and antibiotic resistance research are the most important by far. Cancer treatments steadily improve over time whereas we still have nothing to fight a virus and antibiotics are getting less and less efficacious.
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Re: Wuhan Corona Virus

Postby gbowman » Tue Jan 28, 2020 4:20 am

Thanks! I agree these are important problems. The lack of new antibiotics is particularly troublesome given expanding antibiotic resistance. The Kasson lab stopped participating in FAH some time ago, but my lab has a couple of virus projects going.
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Re: Wuhan Corona Virus

Postby JonazzDJ » Wed Jan 29, 2020 1:17 pm

Thank you for taking some of your precious time to reply. Keep up the good work!
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Re: Wuhan Corona Virus

Postby gbowman » Wed Jan 29, 2020 2:50 pm

Thanks! And thanks all for helping advance science by participating in FAH!
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Re: Wuhan Corona Virus

Postby wuffy68 » Sat Feb 01, 2020 7:46 pm

This discussion leads me to a followon question. The last notable collaborations between China and the folding@home consortium were the Bryostatin studies resulting in some interesting papers. Has the trade war impacted data sharing, and student exchange between the consortium and HKUST who are likely to be on the front line of Corona virus research? Thank you.
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Re: Wuhan Corona Virus

Postby gbowman » Tue Feb 04, 2020 12:03 pm

HKUST had persistent networking issues in the past (the great firewall of China?). They've expressed interest in getting involved again, so we'll see what happens.
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