core A4 P10196-10197,11656-11657 to FAH

[leos]

These two projects are the extended simulations of our previous simulations about Opsin.

These projects aim to understand the dynamics of rhodopsin. Rhodopsin is the protein responsible for detecting light in the eye and triggering a signaling cascade that ultimately results in an electrical stimulus that we perceive as an image. Rhodopsin functions by undergoing a conformational change in response to light. Importantly, mutations to rhodopsin can prevent it from having the desired dynamics, resulting in blindness. This project will allow us to study the dynamics of rhodopsin, set a baseline for understanding the negative effects of such mutations, and potentially yield insight into therapeutic strategies for restoring or preventing vision loss.


core A4
time out 8d
deadline 16d
credit 408