Project 11720 (GPU, Core21) to FAH

Any announcements about FAH policy, servers and new projects will be made here.

Moderators: Site Moderators, PandeGroup

Project 11720 (GPU, Core21) to FAH

Postby rafwiewiora » Mon Sep 03, 2018 7:26 pm

Project 11720 now on FAH!


# atoms: 23329
credit: 4879
k-factor: 0.75
timeout: 7d
deadline: 10d
precision: mixed

The PRC2 complex is a therapeutic target for a number of cancers, currently undergoing clinical trials. It minimally consists of three proteins: EZH2, EED, and SUZ12. Its activity is regulated by a positive feedback loop, where the EED component reads already existing epigenetic marks and activates the EZH2 component to deposit more of them. Projects 11718-20 are looking at the dynamics of the three individual components of the complex (11720 - EZH2). We are studying the allosteric mechanisms that control the functions of this molecular machine, as well as the potential for disrupting these mechanisms for the design of the next generation of inhibitors. Thanks folks!
Posts: 109
Joined: Mon Aug 03, 2015 8:23 pm
Location: New York

Return to Announcements - Pande Group

Who is online

Users browsing this forum: No registered users and 1 guest