Each half of a GTX 590 contains a Fermi chip. FAH has full support for Fermi, Kepler, and Maxwell hardware. The "older hardware" you're referring to is the Tesla architecture (e.g. G8x, G9x, GT20x). Support for Tesla (and earlier) is more limited and may require the special settings.
NVidia has done a good job of maintaining drivers which support FAH's computational requirements.
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