Probably. in cases where transferring data to/from the screen is a limiting factor. If 3D computations by the GPU are the limiting factor, probably not.
For a long time FAH was limited by the compute speed and the common statement was that the speed of the PCIe bus didn't matter. Many of the proteins being processed today are huge in comparison and in those cases, the PCIe bus speed is beginning to matter. (There are a number of discussion on this forum associating numbers with specific configurations.)
The word "speed" consists of a combination of certain latency while the CPU is preparing itself to send/receive the data as well as the transfer speed, once the data starts flowing. Latency for interrupt driven I/O is greater than latency for spin-wait I/O.
All this discussion is certainly off-topic, since we're talking about Windows/Linux/MacOS rather than NaCl.