Folding Forum

For all projects:
<timeout v="1.0"/>
<deadline v="2.0"/>

p17912:
<atoms v="85685"/>
<stats-credit v="54370"/>

p17913:
<atoms v=83,598"/>
<stats-credit v="52037"/>

p17914:
<atoms v= 93,414"/>
<stats-credit v="61233"/>

p17915:
<atoms v= 107,425"/>
<stats-credit v="79305"/>

https://stats.foldingathome.org/project/17914

Hello all,

Thank you to all those who ran these Folding@Home projects. These projects contained simulations of neurotransmitter transporters, protein located in the cell membrane and are responsible for transporting amino acids and neurotransmitters in to cell. However, not much is known about how the cell's internal machinery regulates these proteins. With your help, we were able uncover how the addition of sugar molecules, also known as glycans, affects the structure and dynamics of four critical neurotransmitter transporters which may help develop more effective therapeutic molecules for neurodegenerative disorders.

Please check out the work here if you are interested: https://pubs.acs.org/doi/full/10.1021/acs.jcim.2c00940